Krischek Boris, Narita Akira, Akagawa Hiroyuki, Kasuya Hidetoshi, Tajima Atsushi, Onda Hideaki, Yoneyama Taku, Hori Tomokatsu, Inoue Ituro
Division of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Department of Neurosurgery, Philipps University Hospital, Marburg, Germany.
J Hum Genet. 2006;51(5):491-494. doi: 10.1007/s10038-006-0379-4. Epub 2006 Mar 17.
A linkage region on chromosome 17cen has previously been found in 29 Japanese families with a history of familial intracranial aneurysms (IA). To investigate whether there is evidence of linkage in affected Japanese sib-pairs we performed nonparametric and parametric linkage analysis of a total of 253 familial aneurysm cases including 111 affected sib-pairs (ASP). Ten microsatellite markers covering a 17.7 cM region were chosen, in accordance with previous work in which nominal P had been below 0.05. Statistical analysis was performed by use of Genehunter and Sibpal software. After calculation of the logarithm of the odds (LOD) and nonparametric linkage analysis (NPL) scores our study did not show any linkage in the region analyzed. Our conclusion did not change even after only ASP were analyzed. In contrast with a previous study examining multigenerational Japanese families with IA, most Japanese ASP may not have a genetic linkage to chromosome 17cen.
先前在29个有家族性颅内动脉瘤（IA）病史的日本家庭中发现了17号染色体着丝粒区域的一个连锁区域。为了调查在受影响的日本同胞对中是否存在连锁证据，我们对总共253例家族性动脉瘤病例进行了非参数和参数连锁分析，其中包括111对受影响的同胞对（ASP）。根据之前名义P值低于0.05的研究工作，选择了覆盖17.7 cM区域的10个微卫星标记。使用Genehunter和Sibpal软件进行统计分析。在计算优势对数（LOD）和非参数连锁分析（NPL）分数后，我们的研究在分析区域未显示任何连锁。即使仅分析ASP，我们的结论也没有改变。与之前一项针对有IA的多代日本家庭的研究相比，大多数日本ASP可能与17号染色体着丝粒没有遗传连锁。
Zotero 插件