RrgA和RrgB是由肺炎链球菌rlrA致病岛编码的多亚基菌毛的组成部分。
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.
作者信息
LeMieux Julianna, Hava David L, Basset Alan, Camilli Andrew
机构信息
Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
出版信息
Infect Immun. 2006 Apr;74(4):2453-6. doi: 10.1128/IAI.74.4.2453-2456.2006.
Abstract
The rlrA pathogenicity islet in Streptococcus pneumoniae TIGR4 encodes three surface proteins, RrgA, RrgB, and RrgC, and three sortase enzymes. Using transmission electron microscopy, cell fractionation, cell wall sorting signal domain swapping, and Western blotting, we show that RrgA and RrgB are incorporated into a multisubunit pilus in S. pneumoniae.
摘要
肺炎链球菌TIGR4中的rlrA致病岛编码三种表面蛋白RrgA、RrgB和RrgC以及三种分选酶。通过透射电子显微镜、细胞分级分离、细胞壁分选信号域交换和蛋白质免疫印迹法，我们发现RrgA和RrgB被整合到肺炎链球菌的多亚基菌毛中。
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