Liu En-Bin, Chen Hui-Shu
Department of Pathology, Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, PR China.
Ai Zheng. 2005 Nov;24(11):1416-20.
The diagnosis of lymphoma bone marrow involvement (LBMI) is mainly based on bone marrow biopsy. Pathology of LBMI in Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) are different. The morphology, distribution patterns and immunophenotype of most tumor cells in bone marrow are consistent with those in extramedullary sites, but few may show some discrepancy. This article compared the pathologic features of LBMI in HL, B-NHL and T-NHL, and reviewed advances of bone marrow biopsy pathology in diagnosing LBMI from the aspects of morphology, immunohistochemistry, and lymphoma gene rearrangement.
淋巴瘤骨髓浸润（LBMI）的诊断主要基于骨髓活检。霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）中LBMI的病理学表现有所不同。骨髓中大多数肿瘤细胞的形态、分布模式及免疫表型与髓外部位的肿瘤细胞一致，但也有少数可能存在一些差异。本文比较了HL、B细胞非霍奇金淋巴瘤（B-NHL）和T细胞非霍奇金淋巴瘤（T-NHL）中LBMI的病理特征，并从形态学、免疫组织化学及淋巴瘤基因重排等方面综述了骨髓活检病理在诊断LBMI方面的进展。
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