福氏志贺菌多价疫苗株的构建及血清型特异性免疫评估。
Construction of a multivalent vaccine strain of Shigella flexneri and evaluation of serotype-specific immunity.
作者信息
Jennison Amy V, Roberts Fleur, Verma Naresh K
机构信息
School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, Australia.
出版信息
FEMS Immunol Med Microbiol. 2006 Apr;46(3):444-51. doi: 10.1111/j.1574-695X.2006.00062.x.
Shigella flexneri causes more fatalities by shigellosis than any other Shigella species. There are 13 different serotypes of S. flexneri and their distribution varies between endemic geographical regions. The immune response against S. flexneri is serotype-specific, so current immunization strategies have required the administration of multiple vaccine strains to provide protection against multiple serotypes. In this study, we report the construction of a multivalent S. flexneri vaccine strain, SFL1425, expressing the O-antigen structure specific for serotypes 2a and 5a. This combination of type antigens has not previously been reported for S. flexneri. The multivalent vaccine strain, SFL1425 was able to induce a specific immune response against both serotypes 2a and 5a in a mouse pulmonary model.
福氏志贺菌引起的志贺氏菌病导致的死亡人数比其他任何志贺菌属物种都多。福氏志贺菌有13种不同的血清型，它们在地方性地理区域的分布有所不同。针对福氏志贺菌的免疫反应具有血清型特异性，因此目前的免疫策略需要接种多种疫苗菌株以提供针对多种血清型的保护。在本研究中，我们报告了一种多价福氏志贺菌疫苗菌株SFL1425的构建，该菌株表达针对2a和5a血清型的O抗原结构。这种类型抗原的组合此前尚未见福氏志贺菌的报道。多价疫苗菌株SFL1425能够在小鼠肺部模型中诱导针对2a和5a血清型的特异性免疫反应。
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