实验性白色念珠菌大鼠尿路感染。
Experimental Urinary Tract Infection in Rats Caused by Candida albicans.
机构信息
Squibb Institute for Medical Research, Princeton, New Jersey 08540.
出版信息
Antimicrob Agents Chemother. 1973 Apr;3(4):474-7. doi: 10.1128/AAC.3.4.474.
The increased clinical use of broad-spectrum antibiotics, immunosuppressives, and anti-inflammatory agents is thought to have contributed to the increased incidence of renal infections due to Candida albicans. To aid in the search for improved anticandidal agents, we developed an experimental model in which C. albicans is injected into the medulla of the surgically exposed kidney of the rat. The ensuing infection is restricted to the urinary tract and can be treated successfully with amphotericin B. This model promises to be of merit in the evaluation of agents potentially useful in treating candidiasis of the urinary tract.
广谱抗生素、免疫抑制剂和抗炎药物的临床应用增加，被认为是导致白色念珠菌引起的肾脏感染发病率增加的原因。为了寻找更好的抗真菌药物，我们建立了一个实验模型，即将白色念珠菌注射到手术暴露的大鼠肾脏髓质中。随后的感染仅限于尿路，可以用两性霉素 B 成功治疗。该模型有望在评估潜在用于治疗尿路念珠菌病的药物方面具有价值。
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