右旋苯丙胺用于下丘脑损伤后肥胖和嗜睡的管理。
Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury.
作者信息
Ismail D, O'Connell M A, Zacharin M R
机构信息
Department of Endocrinology, Royal Children's Hospital, Melbourne, Australia.
出版信息
J Pediatr Endocrinol Metab. 2006 Feb;19(2):129-34. doi: 10.1515/jpem.2006.19.2.129.
UNLABELLED
Unrelenting weight gain, morbid obesity and disturbance of the sleep-wake cycle are well-recognized sequelae of hypothalamic injury. These health problems and their risk of significant associated co-morbidity drive the search for potential treatment modalities.
OBJECTIVE
To report effects on weight change and wakefulness in a cohort of 12 patients with structural hypothalamic lesions treated with low-dose dexamphetamine.
METHOD
Retrospective review of case notes.
RESULTS
Twelve patients received dexamphetamine 5 mg twice daily (median duration 13 months in males, 15 months in females). Ten of 12 patients experienced either stabilisation of weight or weight loss on treatment (median loss -0.7 SDS in males, -0.44 SDS in females). Eleven patients reported improvement in daytime wakefulness and/or concentration and exercise tolerance.
CONCLUSION
Low-dose dexamphetamine therapy has a positive impact on inexorable weight gain and daytime somnolence following hypothalamic injury.
未标注
体重持续增加、病态肥胖以及睡眠-觉醒周期紊乱是下丘脑损伤公认的后遗症。这些健康问题及其显著相关合并症的风险促使人们寻找潜在的治疗方式。
目的
报告低剂量右旋苯丙胺治疗12例结构性下丘脑病变患者对体重变化和清醒状态的影响。
方法
回顾病例记录。
结果
12例患者接受每日两次5毫克右旋苯丙胺治疗（男性中位治疗时间13个月，女性15个月）。12例患者中有10例在治疗期间体重稳定或减轻（男性中位体重减轻-0.7 SDS，女性-0.44 SDS）。11例患者报告白天清醒度和/或注意力以及运动耐量有所改善。
结论
低剂量右旋苯丙胺治疗对下丘脑损伤后体重持续增加和白天嗜睡有积极影响。
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