头孢地嗪在老年危重症患者中的单剂量药代动力学

Single-dose pharmacokinetics of cefodizime in critically ill elderly patients.

作者信息

Meyer Brigitte, Traunmueller Friederike, Bojic Andja, Locker Gottfried, Schmid Rainer, Winkler Stefan, Thalhammer Florian

机构信息

Department of Internal Medicine II, Division of Cardiology, Intensive Care Unit, Medical University of Vienna, Vienna, Austria.

出版信息

Int J Antimicrob Agents. 2006 Apr;27(4):335-8. doi: 10.1016/j.ijantimicag.2005.11.018. Epub 2006 Mar 24.

DOI:10.1016/j.ijantimicag.2005.11.018

PMID:16563704

Abstract

Cefodizime is an extended-spectrum third-generation cephalosporin antibiotic that is widely used in the treatment of severe infections of the respiratory and urinary tracts. Pharmacokinetic characteristics of cefodizime were assessed in 13 critically ill elderly patients (median age 73+/-6 years). The mean cefodizime peak serum concentration following a single 2g cefodizime infusion was 219+/-58 mg/L and the mean trough level 12 h after infusion was 29+/-17 mg/L. The elimination half-life was 6.19+/-2.45 h. Total body clearance, area under the plasma concentration-time curve and volume of distribution were 35.8+/-13.2 mL/min, 1089.4+/-505.3 mg h/L and 17.4+/-6.3 L, respectively. Pharmacokinetics of cefodizime in critically ill elderly patients were comparable with those reported previously in healthy volunteers.

摘要

头孢地嗪是一种广谱第三代头孢菌素抗生素，广泛用于治疗呼吸道和泌尿道的严重感染。对13例老年危重症患者（中位年龄73±6岁）评估了头孢地嗪的药代动力学特征。单次输注2g头孢地嗪后，头孢地嗪的平均血清峰浓度为219±58mg/L，输注后12小时的平均谷浓度为29±17mg/L。消除半衰期为6.19±2.45小时。总体清除率、血浆浓度-时间曲线下面积和分布容积分别为35.8±13.2mL/min、1089.4±505.3mg·h/L和17.4±6.3L。老年危重症患者中头孢地嗪的药代动力学与先前在健康志愿者中报道的药代动力学相当。