磁共振波谱法评估胎儿肺成熟度的可行性

Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity.

作者信息

Clifton Matthew S, Joe Bonnie N, Zektzer Andrew S, Kurhanewicz John, Vigneron Daniel B, Coakley Fergus V, Nobuhara Kerilyn K, Swanson Mark G

机构信息

Department of Surgery, University of California-San Francisco, San Francisco, CA 94143-0570, USA.

出版信息

J Pediatr Surg. 2006 Apr;41(4):768-73. doi: 10.1016/j.jpedsurg.2006.02.020.

DOI:10.1016/j.jpedsurg.2006.02.020

PMID:16567191

Abstract

BACKGROUND/PURPOSE: Amniocentesis is an invasive procedure with inherent risks. Magnetic resonance (MR) spectroscopy is a safe noninvasive way of measuring levels of choline-containing compounds (including surfactant) and other metabolites. The purpose of this study was to test the feasibility of assessing fetal lung maturity in vivo and ex vivo using MR spectroscopy to determine differences in amniotic fluid choline concentrations between the second and third trimesters.

METHODS

Magnetic resonance spectroscopy was performed on ex vivo samples of amniotic fluid from second- and third-trimester fetuses. In vivo MR spectroscopy was performed on amniotic fluid and fetal lungs in third-trimester fetuses. Spectral acquisition and analysis were performed by an attending radiologist in conjunction with an MR spectroscopist.

RESULTS

Choline-containing compounds were observed from 3.20 to 3.25 ppm. Comparison of spectra from second- and third-trimester amniocentesis revealed a trend toward increased choline at later gestational ages. Spectra from amniotic fluid and lungs of a third-trimester fetus showed that choline can be detected in the in vivo setting.

CONCLUSIONS

Magnetic resonance spectroscopy is a safe noninvasive procedure that enables measurement of choline-containing compounds in fetal lung and amniotic fluid. Magnetic resonance spectroscopy shows a trend toward an increased quantity of choline in third- vs second-trimester amniocentesis.

摘要

背景/目的：羊膜腔穿刺术是一种具有固有风险的侵入性操作。磁共振（MR）波谱分析是一种安全的非侵入性方法，可用于测量含胆碱化合物（包括表面活性剂）和其他代谢物的水平。本研究的目的是测试使用MR波谱分析在体内和体外评估胎儿肺成熟度的可行性，以确定孕中期和孕晚期羊水胆碱浓度的差异。