在多微生物败血症情况下，迷走神经作为神经与免疫系统之间的联系。
The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis.
作者信息
Kessler Wolfram, Traeger Tobias, Westerholt Alexandra, Neher Friederike, Mikulcak Marlene, Müller Antje, Maier Stefan, Heidecke Claus-Dieter
机构信息
Department of Surgery, Abteilung für Allgemeine Chirurgie, Visceral-Thorax- und Gefässchirurgie, Universitätsklinikum Greifswald der Ernst-Moritz-Arndt-Universität, Friedrich-Loeffler-Strasse 23b, 17475, Greifswald, Germany.
出版信息
Langenbecks Arch Surg. 2006 Apr;391(2):83-7. doi: 10.1007/s00423-006-0031-y. Epub 2006 Mar 28.
BACKGROUND
The role of the vagal nerve in the autonomic nervous system is widely well known. Recently, an additional function was revealed serving as a connector between the nervous and immune system. This connection is called the "cholinergic inflammatory pathway." Through stimulation of the acetylcholine receptors located upon the macrophages, the "unspecific" immune system can be directly influenced.
METHODS
The vagal nerve was completely transected directly posterior to its passage through the diaphragm. The effect of complete vagotomy was analyzed using a murine model of polymicrobial peritonitis (colon ascendens stent peritonitis, CASP). Survival and clinical course of vagotomized or sham-operated mice were analyzed in the CASP model.
RESULTS
After CASP surgery, vagotomy led to a significantly increased mortality (64.7%) in comparison to sham-vagotomized animals (34%). No difference in the bacterial load of various tissues (lung, liver, spleen, blood, lavage fluid, and kidney) from septic animals with or without vagotomy was observed. Vagotomized animals reveal elevated serum cytokine levels (TNF, IL-6, IL-10, and MCP-1) 20 h after the induction of polymicrobial peritonitis.
CONCLUSION
The vagal nerve is therefore an important modulator of the immune system.
背景
迷走神经在自主神经系统中的作用广为人知。最近，其又被揭示出一项额外功能，即作为神经与免疫系统之间的连接者。这种连接被称为“胆碱能炎症通路”。通过刺激巨噬细胞上的乙酰胆碱受体，“非特异性”免疫系统会受到直接影响。
方法
在迷走神经穿过膈肌后直接将其完全切断。使用多微生物性腹膜炎小鼠模型（升结肠支架腹膜炎，CASP）分析完全迷走神经切断术的效果。在CASP模型中分析迷走神经切断或假手术小鼠的存活率和临床病程。
结果
在CASP手术后，与假迷走神经切断动物（34%）相比，迷走神经切断导致死亡率显著增加（64.7%%）。在有或没有迷走神经切断的败血症动物的各种组织（肺、肝、脾、血液、灌洗液和肾脏）的细菌载量上未观察到差异。在多微生物性腹膜炎诱导后20小时，迷走神经切断的动物血清细胞因子水平（TNF、IL-6、IL-10和MCP-1）升高。
结论
因此，迷走神经是免疫系统的重要调节因子。
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