Venkatachalam Taracad K, Qazi Sanjive, Uckun Fatih M
Parker Hughes Institute, Roseville, Minnesota, USA.
Arzneimittelforschung. 2006 Feb;56(2A):152-8. doi: 10.1055/s-0031-1296802.
The distereoisomers of stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2'3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6) were separated using two different procedures. The first method involved separation of the isomers by fractional crystallization, and the second method utilized a preparative HPLC. Both isomers were active against the HIV-1 strain HTLV(IIIB) and neither isomer was more or less active than distereoisomeric mixture of stampidine.
使用两种不同的方法分离了司他帕定(STAMP,DDE - 113,HI - 113,N - [对 -(4 - 溴苯基)- 2'3'-二脱氢 - 3'-脱氧 - 5'-胸苷酰基]-L - 丙氨酸甲酯,CAS 217178 - 62 - 6)的非对映异构体。第一种方法是通过分步结晶分离异构体,第二种方法是使用制备型高效液相色谱法。两种异构体对HIV - 1毒株HTLV(IIIB)均有活性,且两种异构体的活性均不比司他帕定的非对映异构体混合物更强或更弱。