特发性肺纤维化患者的Th1/Th2细胞因子基因多态性
Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis.
作者信息
Vasakova M, Striz I, Slavcev A, Jandova S, Kolesar L, Sulc J
机构信息
Department of Respiratory Diseases, 1 Medical School, Charles University, Faculty Thomayer Hospital, Prague, Czech Republic.
出版信息
Tissue Antigens. 2006 Mar;67(3):229-32. doi: 10.1111/j.1399-0039.2006.00560.x.
We investigated 30 patients with idiopathic pulmonary fibrosis (IPF) and 103 healthy volunteers for the cytokines polymorphisms of the IL-1alpha, IL-1beta, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor-alpha, interferon-gamma, transforming growth factor-beta, IL-1beta, IL-2, IL-4, and IL-4RA genes. The strongest correlation of a genotype with the disease was found for gene polymorphisms at the promotor region of IL-4, where the CT genotypes at the positions (-590) and (-33) were more frequent in the IPF group (P < 0.0001, P(corr) < 0.0022; vs P < 0.0001, P(corr) < 0.0022). Our results support the idea of the pathogenic role of cytokine gene polymorphisms in the etiology and pathogenesis of IPF, with emphasize on the IL-4 promotor gene polymorphisms.
我们对30例特发性肺纤维化（IPF）患者和103名健康志愿者进行了白细胞介素-1α（IL-1α）、白细胞介素-1β（IL-1β）、白细胞介素-1受体（IL-1R）、白细胞介素-1受体拮抗剂（IL-1RA）、白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、白细胞介素-12、肿瘤坏死因子-α、干扰素-γ、转化生长因子-β、白细胞介素-1β、白细胞介素-2、白细胞介素-4和白细胞介素-4受体A（IL-4RA）基因的细胞因子多态性研究。发现IL-4启动子区域的基因多态性与疾病的基因型相关性最强，其中IPF组中（-590）和（-33）位点的CT基因型更为常见（P < 0.0001，校正P < 0.0022；与P < 0.0001，校正P < 0.0022相比）。我们的结果支持细胞因子基因多态性在IPF病因和发病机制中具有致病作用的观点，尤其强调IL-4启动子基因多态性。
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