导致背嵴的常染色体显性突变使罗得西亚背脊犬易患皮样窦。
Autosomal dominant mutation causing the dorsal ridge predisposes for dermoid sinus in Rhodesian ridgeback dogs.
作者信息
Hillbertz N H C Salmon, Andersson G
机构信息
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Biomedical centre, Box 597, S-751 24 Uppsala, Sweden.
出版信息
J Small Anim Pract. 2006 Apr;47(4):184-8. doi: 10.1111/j.1748-5827.2006.00016.x.
OBJECTIVES
To define the mode of inheritance of the dorsal ridge and investigate if the ridge predisposes to the congenital abnormality dermoid sinus in the Rhodesian ridgeback.
METHODS
Segregation analysis was performed, including 87 litters (n=803) produced in Sweden between 1981 and 2002. Data were corrected to avoid bias in the segregation ratio. Chi-squared analysis was performed including 402 litters (n=3598) for the evaluation of a possible genetic correlation between the ridge and dermoid sinus.
RESULTS
The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus. The frequency of ridgeless offspring in the Swedish Rhodesian ridgeback population is estimated to be 5.6 per cent.
CLINICAL SIGNIFICANCE
Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoid sinus.
目的
确定脊背隆起的遗传模式，并研究这种隆起是否会使罗得西亚脊背犬易患先天性异常皮样窦。
方法
进行了分离分析，包括1981年至2002年在瑞典出生的87窝（n = 803只）幼犬。对数据进行了校正以避免分离比例出现偏差。进行了卡方分析，包括402窝（n = 3598只）幼犬，以评估脊背隆起与皮样窦之间可能的遗传相关性。
结果
脊背隆起以常染色体显性模式遗传，且易患皮样窦。据估计，瑞典罗得西亚脊背犬种群中无脊背隆起后代的频率为5.6%。
临床意义
携带脊背隆起特征的罗得西亚脊背犬易患皮样窦。
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