Trovati M
Arch Sci Med (Torino). 1977 Jan-Mar;134(1):1-24.
The literature on glycide-induced lipidogenesis is reviewed. This is an important question also because of its relation to the pathogenesis of pathological conditions such as ketoacidosis, obesity and hypertriglyceridaemia. Doubt is expressed concerning the interpretation of some experimental procedures used in determining the extent of lipidogenesis in man. The questions raised are fully discussed. Their solution is sought via an experiment on the rat involving the comparison of tissue and plasma lipid metabolites values following infusion of a labelled glucose bolus. Little correlation was noted, low plasma levels being found with high tissue radioactivity. It is emphasized that it is very difficult to ideate a valid experimental approach in order to investigate the extent of lipidogenesis in man in vivo: in this respect, the long term risk arising from the use of tracers with a very long half-life (e.g. 14C) in man must be carefully valuated.
本文综述了关于甘油诱导脂肪生成的文献。这也是一个重要问题，因为它与酮症酸中毒、肥胖症和高甘油三酯血症等病理状况的发病机制有关。对于一些用于确定人体脂肪生成程度的实验方法的解释存在疑问。对提出的问题进行了充分讨论。通过一项对大鼠的实验来寻求解决方案，该实验涉及在注射标记葡萄糖推注后比较组织和血浆脂质代谢物的值。结果发现相关性很小，血浆水平低而组织放射性高。需要强调的是，要构思一种有效的实验方法来研究人体内脂肪生成的程度非常困难：在这方面，必须仔细评估在人体中使用半衰期很长的示踪剂（如14C）所带来的长期风险。
