The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet.

作者信息

Negis Yesim, Aytan Nurgül, Ozer Nesrin, Ogru Esra, Libinaki Roksan, Gianello Robert, Azzi Angelo, Zingg Jean-Marc

机构信息

Department of Biochemistry, Faculty of Medicine, Marmara University, 81326 Haydarpasa, Istanbul, Turkey.

出版信息

Arch Biochem Biophys. 2006 Jun 1;450(1):63-6. doi: 10.1016/j.abb.2006.02.027. Epub 2006 Mar 15.

The effect of tocopheryl phosphate on atherosclerosis progression has been studied in rabbits, fed with a 2% cholesterol diet and compared with an equivalent amount of alpha-tocopheryl acetate. The results show that the atherosclerotic-preventing effect of the phosphate derivative was more pronounced than that of the acetate derivative. alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative.