Karp Galia, Maissel Adva, Livneh Etta
Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, 84105 Beer Sheva, Israel.
Cancer Lett. 2007 Feb 8;246(1-2):173-81. doi: 10.1016/j.canlet.2006.02.012. Epub 2006 Mar 31.
Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression cell growth and differentiation. The PKCeta isoform appears as a candidate regulator of mammary gland proliferation or differentiation, as its expression is up-regulated in the mammary gland in the transit from resting to the pregnant state. The purpose of this study was to examine the hormonal regulation of PKCeta. Here we show that estradiol specifically up-regulates the expression of PKCeta in the estrogen-responsive lines MCF-7 and T47D but not in the estrogen non-responsive line MDA-MB 231. Interestingly, the presence of progesterone, involved in the differentiation of the mammary gland, reduced the estrogen-induced PKCeta expression in a time-dependent manner. Thus, our studies suggest that PKCeta has an important role in signalling pathways regulating mammary gland proliferation and its development.
蛋白激酶C（PKC）参与了多条控制基因表达、细胞生长和分化的主要信号转导途径。PKCη亚型似乎是乳腺增殖或分化的候选调节因子，因为在从静止状态转变为妊娠状态时，其在乳腺中的表达会上调。本研究的目的是检测PKCη的激素调节作用。在此我们表明，雌二醇特异性地上调雌激素反应性细胞系MCF-7和T47D中PKCη的表达，但在雌激素无反应性细胞系MDA-MB 231中则不然。有趣的是，参与乳腺分化的孕酮的存在，以时间依赖性方式降低了雌激素诱导的PKCη表达。因此，我们的研究表明，PKCη在调节乳腺增殖及其发育的信号通路中具有重要作用。
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