Yoshida Kenji, Hiratsuka Junichi
Kawasaki Medical School, Department of Radiation Oncology.
Clin Calcium. 2006 Apr;16(4):641- 45.
Bone metastases are one of the most common conditions requiring radiation therapy today. Its main aim is relief of bone pain, prevention of pathological bone fractures as well as its healing, with anticipated effect upon improving mobility, function, and quality of life. For localized bone pain, external beam radiation therapy (EBRT) will be successful in reducing pain in some 80% of patients. However, optimal fraction dose and total doses of EBRT required for pain relief have been unknown. According to the recent reports, carbon ion radiotherapy seems to be a safe and effective modality in the management of metastatic bone tumor not eligible for conventional EBRT. For scattered painful metastases, the systemic administration of radioisotopes is thought to be effective.
骨转移是当今最常见的需要放射治疗的病症之一。其主要目的是缓解骨痛、预防病理性骨折及其愈合,预期对改善活动能力、功能和生活质量有效果。对于局部骨痛,外照射放疗(EBRT)在约80%的患者中能成功减轻疼痛。然而,缓解疼痛所需的EBRT最佳分次剂量和总剂量尚不清楚。根据最近的报告,碳离子放疗似乎是治疗不符合传统EBRT条件的转移性骨肿瘤的一种安全有效的方式。对于散在的疼痛性转移灶,放射性同位素的全身给药被认为是有效的。