环磷腺苷在异丙肾上腺素诱导的雌激素主导的兔子宫松弛中的作用。
Role of cyclic adenosine 3',5'-monophosphate in the isoprenaline-induced relaxation of the oestrogen dominated rabbit uterus.
作者信息
Nesheim B I, Osnes J B, Oye I
出版信息
Br J Pharmacol. 1975 Mar;53(3):403-7. doi: 10.1111/j.1476-5381.1975.tb07376.x.
Abstract
- The role of cyclic adenosine 3',5'-monophosphate (cyclic AMP) in the relaxation produced by isoprenaline in muscle strips from the oestrogen dominated rabbit uterus has been investigated. 2. Isoprenaline 2 times 10- minus 8 M produced an inhibition of the mechanical activity but no increase in cyclic AMP. Isoprenaline 2 times 10- minus 6 M produced both inhibition of mechanical activity and increase in cyclic AMP. 3. The increase in cyclic AMP, but not the inhibition of mechanical activity, was blocked by propranolol 3.4 X 10-MINUS 6 M. 4. Dibutyryl-ccylic AMP produced a relaxation which mimicked that produced by isoprenaline, in that the longitudinal strips were more sensitive than the circular ones. 5. It is concluded that cyclic AMP may be a mediator of the beta-adrenergic effect in the oestrogen dominated rabbit myometrium. However, it seems not to be an obligatory link between stimulation of beta-adrenoceptors and relaxation. Other mechanisms may also exist.
摘要
- 研究了环磷腺苷（cAMP）在雌激素占主导的兔子宫肌条中异丙肾上腺素所产生的舒张作用中的角色。2. 2×10⁻⁸M的异丙肾上腺素可抑制机械活动，但不会使cAMP增加。2×10⁻⁶M的异丙肾上腺素既能抑制机械活动，又能使cAMP增加。3. 3.4×10⁻⁶M的普萘洛尔可阻断cAMP的增加，但不能阻断机械活动的抑制。4. 二丁酰环磷腺苷产生的舒张作用与异丙肾上腺素所产生的相似，即纵行肌条比环形肌条更敏感。5. 得出的结论是，cAMP可能是雌激素占主导的兔子宫肌层中β-肾上腺素能效应的介质。然而，它似乎并非β-肾上腺素能受体刺激与舒张之间的必然联系。可能还存在其他机制。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
Effect of noradrenaline and isoprenaline on the circular and longitudinal muscle of the oestrogen dominated rabbit uterus.去甲肾上腺素和异丙肾上腺素对雌激素主导的兔子宫环形肌和纵行肌的作用。
Acta Pharmacol Toxicol (Copenh). 1972;31(4):296-304. doi: 10.1111/j.1600-0773.1972.tb00685.x.
3
Effect of - and -adrenergic stimulation on the uterine motility and adenosine 3'5'-monophosphate level.α和β肾上腺素能刺激对子宫运动及3',5'-环磷酸腺苷水平的影响。
Can J Physiol Pharmacol. 1971 Nov;49(11):988-98. doi: 10.1139/y71-137.
4
A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
5
Adrenergic influences on uterine smooth muscle.肾上腺素能对子宫平滑肌的影响。
Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):135-48. doi: 10.1098/rstb.1973.0016.
6
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