Biochemistry Laboratory, Department of Botany, University of North Carolina, Chapel Hill, North Carolina 27514.
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3769-72. doi: 10.1073/pnas.79.12.3769.
Selected species of the order Peronosporales, which are unable to epoxidize squalene and thus synthesize sterols, are able to metabolize exogenous cycloartenol to lanosterol and in some organisms to fucosterol, ergosterol, and cholesterol. Lanosterol was less effectively utilized but some ergosterol and cholesterol were yielded. Fucosterol was very efficiently metabolized by most species to ergosterol, Delta(7)-ergostenol, Delta(5)-ergostenol, cholestanol, and cholesterol. Several unknown sterols were observed in most trials. These data suggest a vestigial sterol synthetic pathway derived from cycloartenol, followed by possible isomerization to lanosterol and then to other sterols.
被选择的属单子叶植物,它们不能环氧化鲨烯和因此合成固醇,能够代谢外源羊毛甾醇为胆甾醇醇和在一些生物体中为麦角甾醇、粪甾醇和胆固醇。羊毛甾醇被较不有效地利用但是一些麦角甾醇和胆固醇被产生。粪甾醇被最多数物种非常有效地代谢为麦角甾醇、Delta(7)-麦角甾醇醇、Delta(5)-麦角甾醇醇、胆甾醇和胆固醇。一些未知的固醇在多数试验中被观察。这些数据建议来源于羊毛甾醇的退化的固醇合成途径,然后可能异构化为胆甾醇醇和然后为其他固醇。