Reimer S Brent, Kittleson Mark D, Kyles Andrew E
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, USA.
J Vet Intern Med. 2006 Mar-Apr;20(2):290-6. doi: 10.1892/0891-6640(2006)20[290:uortit]2.0.co;2.
The purpose of this prospective clinical trial was to evaluate the safety and efficacy of a commercially available rheolytic thrombectomy system in the treatment of naturally occurring feline aortic thromboembolic disease. All 6 cats enrolled in the investigation were affected at the level of the distal aorta and had signs of the disease affecting both pelvic limbs. Cats were anesthetized and an arteriotomy was performed on 1 carotid artery to gain access to the arterial system. Selective arterial angiography was used to confirm the presence of thromboembolic disease. The thrombectomy system was advanced to the level of the thrombus using fluoroscopic guidance. Repeat angiography was used intermittently to assess progress of thromboembolus dissolution throughout the procedure. The use of the rheolytic thrombectomy system resulted in successful thrombus dissolution in 5 of 6 cats. Three of 6 cats survived to discharge. Both of these results compare favorably with conventional therapies used in the treatment of this disease. Feline distal aortic thromboembolism is a frustrating disease that warrants a guarded to poor prognosis. Rheolytic thrombectomy may provide veterinarians with an alternative therapy in the treatment of thromboembolic diseases, including feline distal aortic thromboembolism.
这项前瞻性临床试验的目的是评估一种市售的血栓溶解切除术系统在治疗自然发生的猫主动脉血栓栓塞性疾病中的安全性和有效性。参与该研究的所有6只猫均在主动脉远端出现病变,且有影响双后肢的疾病体征。猫被麻醉后,在一条颈动脉上进行动脉切开术以进入动脉系统。使用选择性动脉血管造影来确认血栓栓塞性疾病的存在。在荧光镜引导下,将血栓切除术系统推进到血栓部位。在整个手术过程中,间歇性地使用重复血管造影来评估血栓溶解的进展情况。6只猫中有5只使用血栓溶解切除术系统后成功溶解了血栓。6只猫中有3只存活至出院。这两个结果与用于治疗该疾病的传统疗法相比都更具优势。猫主动脉远端血栓栓塞是一种令人沮丧的疾病,预后通常不佳。血栓溶解切除术可能为兽医治疗包括猫主动脉远端血栓栓塞在内的血栓栓塞性疾病提供一种替代疗法。