Ciray Haydar Nadir, Karagenç Levent, Ulug Ulun, Bener Faruk, Bahçeci Mustafa
Bahceci Women Health Care Center, German Hospital, Istanbul, Turkey.
Fertil Steril. 2006 Feb;85(2):358-65. doi: 10.1016/j.fertnstert.2005.07.1301.
To assess the development and implantation potential of early-cleaved embryos displaying various morphological patterns.
Retrospective analysis.
Private IVF center.
PATIENT(S): Embryos obtained from 1,556 transfer cycles were assessed. Early-cleaved embryos were grouped according to their cleavage patterns as: even (1,490); uneven (3,238); and fragmented (768), or according to nuclear morphologies as: mononucleation (2,008) and other nuclear morphologies; nonmononucleation (3,488). Seven thousand four hundred forty-five embryos were late cleaved.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Embryo quality, pregnancy (PR), and implantation rates.
RESULT(S): Day 3 embryo quality was highest in evenly early-cleaved embryos and in those displaying mononucleation. Early-cleaved embryos displaying fragmentation and late-cleaved embryos yielded the poorest day 3 quality. Early cleavage cycles displayed higher PR and implantation rate than late cleavage with the exception of other nuclear morphologies, in which similar outcome was obtained. Mononucleated early-cleaved embryos implanted at a higher frequency than early-cleaved embryos displaying other nuclear morphologies.
CONCLUSION(S): The morphology of early cleavage correlates to day 3 embryo quality and implantation rate.
评估呈现不同形态模式的早期分裂胚胎的发育及着床潜力。
回顾性分析。
私立体外受精中心。
评估了从1556个移植周期中获得的胚胎。早期分裂胚胎根据其分裂模式分组为：均匀分裂（1490个）；不均匀分裂（3238个）；以及碎片化（768个），或者根据核形态分组为：单核（2008个）和其他核形态；非单核（3488个）。7445个胚胎为晚期分裂。
无。
胚胎质量、妊娠率（PR）和着床率。
第3天胚胎质量在均匀早期分裂胚胎和呈现单核的胚胎中最高。呈现碎片化的早期分裂胚胎和晚期分裂胚胎的第3天质量最差。除其他核形态外，早期分裂周期的妊娠率和着床率高于晚期分裂，在其他核形态中获得了相似的结果。单核早期分裂胚胎的着床频率高于呈现其他核形态的早期分裂胚胎。
早期分裂的形态与第3天胚胎质量和着床率相关。
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