毫米波对环磷酰胺诱导的核因子κB的影响。

Effect of millimeter waves on cyclophosphamide induced NF-kappaB.

作者信息

Logani M K, Natarajan M, Makar V R, Bhanushali A, Ziskin M C

机构信息

Richard J. Fox Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA.

出版信息

Electromagn Biol Med. 2006;25(1):23-7. doi: 10.1080/15368370600572946.

DOI:10.1080/15368370600572946

PMID:16595331

Abstract

Antiapoptotic activity of NF-Kappa B (NF-kappaB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-kappaB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-kappaB DNA-binding activity as compared to the control group. No significant enhancement in NF-kappaB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-kappaB induced by chemotherapeutic drugs.

摘要

核因子-κB（NF-κB）在肿瘤中的抗凋亡活性有助于肿瘤获得化疗耐药性。本研究在小鼠脾脏中探讨了毫米波（MMW）对环磷酰胺（CPA）诱导的NF-κB激活的影响。抗癌药物CPA可使NF-κB DNA结合活性相较于对照组显著增加（58.9倍）。当CPA组同时接受MMW照射时，未观察到NF-κB活性有明显增强（0.51倍）。这些结果表明，MMW治疗可抑制化疗药物诱导的NF-κB激活。