Minkauskiene M, Nadisauskiene R J, Padaiga Z
Clinic of Obstetrics and Gynecology, Kaunas University of Medicine Kaunas, Lithuania.
Int J Fertil Womens Med. 2006 Jan-Feb;51(1):39-46.
To measure the incidence of severe acute maternal morbidity (SAMM) and to find the risk factors that could be useful in trying to predict the development of SAMM.
The data were collected prospectively in 7 maternity units from different Lithuanian regions over a 1-year period. Every woman with a clinical diagnosis of severe preeclampsia, eclampsia, Hemolysis, Elevated Liver enzymes, and Low Platelet count (HELLP) syndrome, severe hemorrhage, uterine rupture, or severe sepsis during pregnancy or delivery or until the 42nd day post partum was included after verification of diagnosis by using clinical criteria.
One hundred and six cases of SAMM and one maternal death were identified during the study among 13,399 deliveries (7.91/1000 deliveries 95% CI 6.48-9.56). There were 57 cases of severe preeclampsia, 3 cases of eclampsia, 38 cases of severe hemorrhage, 3 cases of uterine rupture, and 4 cases of severe sepsis. One maternal death occurred due to HELLP syndrome, so the case-fatality ratio for severe morbidity was 0.99%.
The incidence of SAMM and case-fatality rate in Lithuania are similar to those in other European countries. The main risk factors for SAMM were previous peripartum hemorrhage, previous hypertension, previous renal diseases, lack of antenatal care, and dystocia.
测量严重急性孕产妇发病(SAMM)的发生率,并找出有助于预测SAMM发生发展的危险因素。
在1年的时间里,前瞻性收集立陶宛不同地区7个产科单位的数据。每一位在孕期、分娩期间或产后42天内临床诊断为重度子痫前期、子痫、溶血、肝酶升高和血小板减少(HELLP)综合征、严重出血、子宫破裂或严重脓毒症的妇女,经临床标准核实诊断后纳入研究。
在该研究期间,13399例分娩中确诊106例SAMM,1例孕产妇死亡(7.91/1000例分娩,95%可信区间6.48 - 9.56)。其中重度子痫前期57例,子痫3例,严重出血38例,子宫破裂3例,严重脓毒症4例。1例孕产妇因HELLP综合征死亡,因此严重发病的病死率为0.99%。
立陶宛SAMM的发生率和病死率与其他欧洲国家相似。SAMM的主要危险因素为既往围产期出血、既往高血压、既往肾脏疾病、缺乏产前检查和难产。