[肽YY 3-36与饮食诱导的肥胖抵抗大鼠之间的关系]

Wang Chong-Jian, Yang Nian-Hong, Xu Ming-Jia, Wu Song-Wen, Yang Xuefeng, Liu Liegang, Sun Xiufa

Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.

Wei Sheng Yan Jiu. 2006 Jan;35(1):49-51.

OBJECTIVE

To study the plasma concentration of peptide YY3 - 36 (PYY3-36) and the expression levels of PYY mRNA of ileum and colon in dietary induced obesity (DIO) and dietary induced obesity resistant (DIO-R) rats and the relation between PYY3-36 and DIO-R rats.

METHODS

Thirty-six female SD rats were randomly divided into high-fat diet group (n = 27) and chow fed control group (n = 9), after 13 weeks of either a high-fat diet or chew fed diet, the high-fat diet group was subdivided into DIO and DIO-R group according to the final body weight. Weight gain, caloric intake, the concentration of PYY3-36 and the expression levels of PYY mRNA were measured and compared.

RESULTS

The total caloric intake of DIO-R rats was lower than DIO rats (P < 0.01), while no significant difference was found between DIO-R and control rats (P > 0.05). The concentration of PYY3-36 and the expressions of PYY mRNA of ileum and colon in DIO-R rats were higher significantly than that of the DIO and control rats (P < 0.01), while no significant difference was found between DIO and control group (P > 0.05), except that PYY mRNA of ileum was advanced in DIO group (P < 0.01).

CONCLUSION

On the High-fat diet, SD rats showed different susceptibility to obese and energy intake, increased levels of PYY3-36 and PYY mRNA might be related to dietary induced obesity resistant.

目的

研究饮食诱导肥胖（DIO）大鼠和饮食诱导肥胖抵抗（DIO-R）大鼠血浆中肽YY3-36（PYY3-36）的浓度以及回肠和结肠中PYY mRNA的表达水平，以及PYY3-36与DIO-R大鼠之间的关系。

方法

将36只雌性SD大鼠随机分为高脂饮食组（n = 27）和普通饮食对照组（n = 9），在给予高脂饮食或普通饮食13周后，根据最终体重将高脂饮食组再细分为DIO组和DIO-R组。测量并比较体重增加、热量摄入、PYY3-36浓度以及PYY mRNA的表达水平。

结果

DIO-R大鼠的总热量摄入低于DIO大鼠（P < 0.01），而DIO-R大鼠与对照大鼠之间无显著差异（P > 0.05）。DIO-R大鼠回肠和结肠中PYY3-36的浓度以及PYY mRNA的表达显著高于DIO大鼠和对照大鼠（P < 0.01），而DIO组和对照组之间无显著差异（P > 0.05），但DIO组回肠的PYY mRNA有所升高（P < 0.01）。