Al-Moundhri M S, Al-Bahrani B, Burney I A, Nirmala V, Al-Madhani A, Al-Mawaly K, Al-Nabhani M, Thomas V, Ganguly S S, Grant C S
Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University (SQU), Muscat, Oman.
Oncology. 2006;70(2):90-6. doi: 10.1159/000092584. Epub 2006 Apr 4.
Gastric cancer is the most common cancer in Oman and a leading cause of cancer death. The variation in survival rates between countries and ethnic groups has been attributed to early detection policies, differences in clinicopathological features, treatment approaches, and biological characteristics. There were no previous reports on gastric cancer from Oman and very few studies on Asian Arabs.
To evaluate the impact of clinicopathological and treatment variables on the survival prospects of Omani Arab patients diagnosed with gastric cancer.
The medical records of 339 Omani Arab patients diagnosed with invasive gastric adenocarcinoma during the period 1993-2004 were retrospectively reviewed. The relative importance of clinicopathological features and surgical and medical treatments were assessed using univariate and multivariate analyses.
Most patients had distal ulcerating-type gastric cancer and presented at advanced stages. The median survival time for the entire cohort was 12 months (95% CI 9.7-14.4) with a 5-year overall survival rate of 16.7%. On univariate analysis of 237 patients who underwent surgical resection, the following positive prognostic factors emerged as significant: early overall TNM stage, early T stage, negative lymph nodes, tumor size <5 cm, ulcerating macroscopic appearance, and curative surgical attempt. The independent prognostic factors on multivariate analysis were T stage and lymph node involvement.
The overall T and N stages are the most important determining factor for survival in Omani Arab patients. More efforts need to be made for the early detection of gastric cancer in developing countries such as Oman, while continuing to employ the standard surgical and medical treatments.
胃癌是阿曼最常见的癌症，也是癌症死亡的主要原因。不同国家和种族群体的生存率差异归因于早期检测政策、临床病理特征差异、治疗方法和生物学特性。此前没有关于阿曼胃癌的报道，对亚洲阿拉伯人的研究也很少。
评估临床病理和治疗变量对被诊断为胃癌的阿曼阿拉伯患者生存前景的影响。
回顾性分析了1993年至2004年期间339例被诊断为浸润性胃腺癌的阿曼阿拉伯患者的病历。使用单因素和多因素分析评估临床病理特征以及手术和药物治疗的相对重要性。
大多数患者患有远端溃疡型胃癌，且就诊时已处于晚期。整个队列的中位生存时间为12个月（95%可信区间9.7 - 14.4），5年总生存率为16.7%。对237例行手术切除的患者进行单因素分析时，出现了以下显著的阳性预后因素：早期总体TNM分期、早期T分期、淋巴结阴性、肿瘤大小<5 cm、溃疡型大体外观以及根治性手术尝试。多因素分析的独立预后因素为T分期和淋巴结受累情况。
总体T和N分期是阿曼阿拉伯患者生存的最重要决定因素。在阿曼等发展中国家，在继续采用标准手术和药物治疗的同时，需要做出更多努力以早期发现胃癌。
