使用木薯属植物对醛和酮进行生物还原

Bioreduction of aldehydes and ketones using Manihot species.

作者信息

Machado Luciana L, Souza João Sammy N, de Mattos Marcos Carlos, Sakata Solange K, Cordell Geoffrey A, Lemos Telma L G

机构信息

Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60451-970 Fortaleza-Ceara, Caixa Postal 60021, Brazil.

出版信息

Phytochemistry. 2006 Aug;67(15):1637-43. doi: 10.1016/j.phytochem.2006.02.008. Epub 2006 Apr 5.

DOI:10.1016/j.phytochem.2006.02.008

PMID:16603212

Abstract

Biocatalysis constitutes an important tool in organic synthesis, especially for the preparation of chiral molecules of biological interest. A series of aliphatic and aromatic aldehydes and two ketones were reduced using plant cell preparations from Manihot esculenta and Manihot dulcis roots. The reduced products were typically obtained in excellent yields (80-96%), and with excellent enantiomeric excess (94-98%), except for vanillin. Esters, a nitrile, and an amide were also examined, but were not reduced. Preliminary conversion rate studies are reported. This is the first attempt to perform the biotransformation of carbonyl compounds using Manihot species.

摘要

生物催化是有机合成中的一种重要工具，尤其适用于制备具有生物学意义的手性分子。使用来自木薯和甜木薯根的植物细胞制剂还原了一系列脂肪族和芳香族醛以及两种酮。除香草醛外，还原产物的产率通常很高（80 - 96%），对映体过量率也很高（94 - 98%）。还研究了酯、腈和酰胺，但它们未被还原。报道了初步的转化率研究。这是首次尝试使用木薯属植物进行羰基化合物的生物转化。