神经无症状老年个体脊髓中的α-突触核蛋白病理学
Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals.
作者信息
Klos K J, Ahlskog J E, Josephs K A, Apaydin H, Parisi J E, Boeve B F, DeLucia M W, Dickson D W
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
出版信息
Neurology. 2006 Apr 11;66(7):1100-2. doi: 10.1212/01.wnl.0000204179.88955.fa.
The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
作者评估了60岁以上无神经系统症状个体（N = 106）脊髓α-突触核蛋白病变的发生率。采用α-突触核蛋白免疫组织化学方法，9例（8%）在中间外侧柱有偶发性路易小体神经突，迷走神经背运动核、蓝斑和中缝核至少有一些α-突触核蛋白病变。除2例之外，在所有病例的黑质、基底前脑、杏仁核或皮质中也检测到了稀疏的α-突触核蛋白病变。
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