Streangă Violeta, Nistor N, Dimitriu A G, Cristogel F, Jităreanu Cristina, Frasin Mariana
Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi Facultatea de Medicină Clinica I Pediatrie.
Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun;109(2):251-3.
Amitriptyline (Antideprin) determines severe intoxications, especially because of its cardiac side effects.
We studied 8 children (2-14 years old) admitted with signs of amitriptyline intoxication.
The clinical picture revealed altered general status, generalized hypertonia, arterial hypotension up to collapse, mydriasis, coma and cardiac arrhythmia. ECG monitoring showed ventricular premature beats, isolated, couplets and triplets, ventricular tachycardia and torsade des points, severe ventricular repolarisation disturbances with diffuse subendocardial ischemia. The treatment consisted in: gastric lavage with activated charcoal, alkalinisation with sodium bicarbonate, antiarrhythmic drugs and sustained vital functions. All cases recovered in 4-6 days.
The severity of amitriptyline intoxication requires continue clinical and ECG monitoring, for early detection of some life threatening cardiovascular events. Thus, the treatment will be started early and will alleviate the severe prognosis of this intoxication.
阿米替林（安拿芬尼）可导致严重中毒，尤其是因其心脏副作用。
我们研究了8名因阿米替林中毒症状入院的儿童（2至14岁）。
临床表现为一般状况改变、全身肌张力增高、直至休克的动脉低血压、瞳孔散大、昏迷及心律失常。心电图监测显示室性早搏、单发、成对及三联律、室性心动过速及尖端扭转型室速、伴有弥漫性心内膜下缺血的严重心室复极紊乱。治疗包括：用活性炭洗胃、用碳酸氢钠碱化、抗心律失常药物及维持生命功能。所有病例均在4至6天内康复。
阿米替林中毒的严重性需要持续的临床及心电图监测，以便早期发现一些危及生命的心血管事件。因此，治疗应尽早开始，以改善这种中毒的严重预后。
Zotero 插件