Neagu Anca, Muscă Simona, Slătineanu S, Pricop M
Universitatea de Medicină i Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a IV-a Obstetrică-Ginecologie.
Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun;109(2):276-80.
Prognostic factors predict the long term outcome of treatment, recurrence rate and overall survival. Treatment decision is based on assessment of prognostic factors. They are classified as clinical (age, menopausal status, tumoral growth rate, inflammatory signs), histological (tumoral stage, pathological type, grading, tumoral necrosis, lymph nodes status, margins status) and biological factors (steroidal receptors pattern, ploidy etc). There are tumor markers currently evaluated, being considered conventional and new markers that are not usually evaluated. Patients with negative lymph node will show no recurrences after surgery and/or radiotherapy in 70% of the cases. Factors with specific prognostic value are used for deciding on the therapeutic strategy in negative axillary node cases.
预后因素可预测治疗的长期结果、复发率和总生存率。治疗决策基于对预后因素的评估。它们可分为临床因素(年龄、绝经状态、肿瘤生长速度、炎症体征)、组织学因素(肿瘤分期、病理类型、分级、肿瘤坏死、淋巴结状态、切缘状态)和生物学因素(甾体受体模式、倍性等)。目前正在评估一些肿瘤标志物,包括传统标志物和通常未评估的新型标志物。淋巴结阴性的患者在70%的病例中术后和/或放疗后不会复发。具有特定预后价值的因素用于决定腋窝淋巴结阴性病例的治疗策略。