Apostu M, Bibire Nela, Dorneanu V
Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.
Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun;109(2):422-5.
Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.
法莫替丁属于H2拮抗剂类，是一种含有噻唑部分的化合物，用于消化性溃疡治疗。本文探讨了利用法莫替丁与苦酮酸之间的反应开发一种新的紫外分光光度法评估的可能性。我们在362nm处进行测定，此时法莫替丁 - 苦酮酸络合物的吸光度最大，并确定了最佳反应条件。该方法已成功应用于药物剂型中法莫替丁的含量测定。
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