Li Li, Chen Zeng-Rong, Zhang Yi, Wang Xiao-Dong, Shu Ye, Zhou Zong-Guang, Li Ka
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Mar;37(2):295-7.
To assess the relationship between the incidence and prognostic significance of mesorectal involvement.
328 cases of rectal cancer resected with total or subtotal mesorectal excision in our hospital from Jan. 1997 to Dec. 1998 were followed up and analyzed in this study. The neoplastic foci were identified at the pathologic examination of the mesorectum.
Neoplastic mesorectal metastasis was found in 234 cases (71.3%); node involvement in 59.8% and microscopic foci involvement in 36% of all cases (isolated in 11.6%, microfoci alone without any kind of other mesorectal involvement). Microscopic deposits were found in 10.3% of TNM Stage I tumors, in 18.4% of Stage II and in 45.1% of Stage III cancers. Five-year disease-free survival rate (49.6% vs. 91.4%) were observed in patients with mesorectal involvement, compared with those without deposits.
The incidence of neoplastic foci in the mesorectum seem to affect prognosis, even in early staged tumors. The presence of mesorectal foci should be considered an index in modifying the conventional staging of the rectal tumor.
评估直肠系膜受累的发生率及其预后意义之间的关系。
本研究对1997年1月至1998年12月在我院接受全直肠系膜或次全直肠系膜切除的328例直肠癌患者进行随访和分析。在直肠系膜的病理检查中确定肿瘤病灶。
234例（71.3%）发现直肠系膜肿瘤转移；所有病例中淋巴结受累占59.8%，微小病灶受累占36%（孤立微小病灶占11.6%，仅微小病灶而无任何其他类型的直肠系膜受累）。在TNM I期肿瘤中，10.3%发现微小转移灶；II期为18.4%；III期为45.1%。与无转移灶的患者相比，直肠系膜受累患者的5年无病生存率为49.6% 对91.4%。
即使在早期肿瘤中，直肠系膜肿瘤病灶的发生率似乎也会影响预后。直肠系膜病灶的存在应被视为修正直肠癌传统分期的一个指标。
Zotero 插件