Sammeth Michael, Heringa Jaap
Centre for Integrative Bioinformatics (IBIVU), Vrije Universiteit, Amsterdam, The Netherlands.
Proteins. 2006 Jul 1;64(1):263-74. doi: 10.1002/prot.20957.
Repeating fragments in biological sequences are often essential for structure and function. Over the years, many methods have been developed to recognize repeats or to multiply align protein sequences. However, the integration of these two methodologies has been largely unexplored to date. Here, we present a new method capable of globally aligning multiple input sequences under the constraints of a given repeat analysis. The method supports different stringency modes to adapt to various levels of detail and reliability of the repeat information available.
生物序列中的重复片段通常对结构和功能至关重要。多年来，已经开发了许多方法来识别重复序列或对蛋白质序列进行多重比对。然而，到目前为止，这两种方法的整合在很大程度上尚未得到探索。在这里，我们提出了一种新方法，能够在给定重复分析的约束下对多个输入序列进行全局比对。该方法支持不同的严格模式，以适应可用重复信息的各种详细程度和可靠性。
