Einarson Adrienne
The Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, The University of Toronto, Ontario, Canada.
MedGenMed. 2005 Oct 5;7(4):3.
A substantial number of women of childbearing age are prescribed psychotropic drugs, and because nearly 50% of pregnancies are unplanned, many women are still taking them upon becoming pregnant. This article reviews the various classes of psychotropic drugs that are commonly used to treat psychiatric disorders--antidepressants, benzodiazepines, antipsychotics, antiepileptics, lithium and monoamine oxidase (MAO) inhibitors--in terms of their safety during pregnancy. Evidence-based information from epidemiologic studies indicates that most psychotropic drugs are relatively safe for use during pregnancy. There is also an increasingly large body of evidence-based information in the literature indicating that it may be more harmful to both the mother and her baby if she is not treated appropriately when suffering from a severe psychiatric disorder. Therefore, it is important for women with psychiatric disorders and their healthcare providers to have access to evidenced-based information about the safety of these drugs when taken during pregnancy to ensure that women make an informed decision as to whether they should continue with the pharmacotherapy they have been using to treat their condition.
大量育龄妇女被开具精神类药物，而且由于近50%的怀孕是意外怀孕，许多女性在怀孕时仍在服用这些药物。本文就常用的各类治疗精神疾病的精神类药物——抗抑郁药、苯二氮䓬类药物、抗精神病药、抗癫痫药、锂盐和单胺氧化酶（MAO）抑制剂——在孕期的安全性进行综述。来自流行病学研究的循证信息表明，大多数精神类药物在孕期使用相对安全。文献中也有越来越多的循证信息表明，如果患有严重精神疾病的女性未得到适当治疗，对母亲和胎儿可能更有害。因此，患有精神疾病的女性及其医疗保健提供者能够获取关于这些药物孕期使用安全性的循证信息非常重要，以确保女性能够就是否继续使用一直用于治疗自身疾病的药物疗法做出明智的决定。
