Khorram-Manesh Amir, Ardakani Jalal Vahedian, Behjati Hamid Reza, Nylund Gunnar, Delbro Dick
Department of Surgery, Kungälv Hospital, Kungälv, Sweden.
Dig Dis Sci. 2006 Mar;51(3):560-5. doi: 10.1007/s10620-006-3170-7.
People addicted to opium rarely develop intra-abdominal adhesions after abdominal surgery. We aimed to evaluate the effect of opium or morphine on preventing postoperative adhesions in rats. Sixty-three rats were randomly divided into a control group, opium-addicted group, and morphine-addicted group in a double-blind study. Drug dependency was checked by using naloxone. Animals were then operated on and the cecum was abraded. At reoperation 3 weeks later the magnitude of adhesions was evaluated by a scoring system. There was a significant difference between the control, opium-addicted, and morphine-addicted groups with regard to the length (P < .001), thickness (P < .05), and severity of adhesions (P < .05). Opium or morphine reduces the severity of postoperative adhesions. Elucidation of the opioid receptor(s) involved in this process would enable the use of selective ligands and offer a pharmacologic strategy in preventing adhesion formation.
吸食鸦片成瘾的人腹部手术后很少发生腹腔粘连。我们旨在评估鸦片或吗啡对预防大鼠术后粘连的作用。在一项双盲研究中，63只大鼠被随机分为对照组、鸦片成瘾组和吗啡成瘾组。使用纳洛酮检查药物依赖性。然后对动物进行手术并擦伤盲肠。3周后再次手术时，通过评分系统评估粘连程度。对照组、鸦片成瘾组和吗啡成瘾组在粘连长度（P <.001）、厚度（P <.05）和粘连严重程度（P <.05）方面存在显著差异。鸦片或吗啡可降低术后粘连的严重程度。阐明参与此过程的阿片受体将有助于使用选择性配体，并为预防粘连形成提供一种药理学策略。
