Scheike Thomas H, Keiding Niels
Department of Biostatistics, University of Copenhagen, Oster Farimagsgade 5, entr. B, PO Box 2099, DK-1014 Copenhagen K, Denmark.
Stat Methods Med Res. 2006 Apr;15(2):127-40. doi: 10.1191/0962280206sm435oa.
Time-to-pregnancy(TTP), the duration that a couple waits from initiating attempts to conceive until conception occurs, is regarded as one of the direct measures of natural fecundity. Statistical tools for designing and analysing TTP studies belong to the general area of survival analysis, but several special features have been developed: it is customary to work in discrete time, and random heterogeneity between couples has always played a prominent role. This review works on this background with focus on how to perform valid analyses, under various prospective, retrospective and cross-sectional sampling frames. We illustrate using examples from our own experience.
受孕时间（TTP），即一对夫妇从开始尝试受孕到成功受孕所等待的时间，被视为自然生育能力的直接衡量指标之一。用于设计和分析TTP研究的统计工具属于生存分析的一般领域，但也有一些特殊之处：通常在离散时间内进行研究，夫妇之间的随机异质性一直起着重要作用。本综述在此背景下展开，重点关注在各种前瞻性、回顾性和横断面抽样框架下如何进行有效的分析。我们将通过自身经验中的实例进行说明。
