Bartholin Laurent, Wessner Lisa L, Chirgwin John M, Guise Theresa A
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Aurbach Medical Research Building, Charlottesville, VA 22908, USA.
Cancer Lett. 2007 Feb 8;246(1-2):230-6. doi: 10.1016/j.canlet.2006.02.019. Epub 2006 Apr 17.
Cyr61 is a multifunctional protein that can stimulate angiogenesis and tumor growth. Its expression by many cancers and breast cancers increases with tumor grade. Cyr61 is closely related to connective tissue growth factor, CTGF. Both proteins regulate skeletal development, suggesting that they could contribute to breast cancer metastases to bone, a process regulated by TGFbeta. We show that Cyr61 transcription is activated by TGFbeta and that the human Cyr61 promoter contains consensus sequences that bind Smad proteins. TGFbeta in the tumor microenvironment may stimulate cancer metastases to sites such as bone by increasing Cyr61 expression and secretion.
Cyr61是一种多功能蛋白，可刺激血管生成和肿瘤生长。许多癌症包括乳腺癌中其表达随肿瘤分级增加。Cyr61与结缔组织生长因子CTGF密切相关。这两种蛋白均调节骨骼发育，提示它们可能促进乳腺癌向骨转移，这一过程由转化生长因子β（TGFβ）调控。我们发现TGFβ可激活Cyr61转录，且人类Cyr61启动子含有与Smad蛋白结合的共有序列。肿瘤微环境中的TGFβ可能通过增加Cyr61表达和分泌来刺激癌症向骨等部位转移。
