Begovac Josip, Lisić Miroslav, Lukas Davorka, Maretić Tomislav, Kniewald Tihana, Novotny Thomas E
Department of HIV/AIDS, University Hospital of Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia.
Coll Antropol. 2006 Mar;30(1):175-9.
We compared the survival of patients following the first AIDS event in Croatia from the period 1986-1996 to the period 1997-2000. A total of 72 (81.8%) out of 88 patients from 1986-1996 and 18 (32.1%) out of 56 from 1997-2000 died. Survival following the first AIDS-defining illness markedly improved in the period 1997-2000 compared to the period 1986-1996 (adjusted Hazard Ratio (HR) for patients surviving more than 6 months: 0.11, 95% confidence interval (95% CI) = 0.04-0.29). A CD4+ cell count of < 100 x 10(6)/L was an independent risk factor for patients surviving up to 2 years (adjusted HR = 1.96, 95% CI = 1.1-3.43, p = 0.02). Patients with tuberculosis or fungal infections had a longer survival when compared to other diagnosis (adjusted HR = 0.53, 95% CI = 0.32-0.90, p = 0.01). However, despite dramatic survival benefit of combination antiretroviral therapy, mortality at six months following the first AIDS event was similar in the two study periods and the one-year probability of death was still substantial (27.2%) in the period 1997-2000.
我们比较了克罗地亚1986 - 1996年期间首次出现艾滋病事件后患者的生存率与1997 - 2000年期间的生存率。1986 - 1996年的88例患者中有72例（81.8%）死亡，1997 - 2000年的56例患者中有18例（32.1%）死亡。与1986 - 1996年相比，1997 - 2000年首次出现艾滋病定义疾病后的生存率有显著提高（存活超过6个月患者的调整后风险比（HR）：0.11，95%置信区间（95%CI）= 0.04 - 0.29）。CD4 +细胞计数<100×10⁶/L是存活长达2年患者的独立危险因素（调整后HR = 1.96，95%CI = 1.1 - 3.43，p = 0.02）。与其他诊断相比，患有结核病或真菌感染的患者生存期更长（调整后HR = 0.53，95%CI = 0.32 - 0.90，p = 0.01）。然而，尽管联合抗逆转录病毒疗法带来了显著的生存益处，但两个研究期间首次出现艾滋病事件后6个月的死亡率相似，1997 - 2000年期间1年的死亡概率仍然很高（27.2%）。
