1985 - 2004年丹麦北部卵巢癌患者生存率提高

Improved survival of patients with ovarian cancer in Northern Denmark, 1985-2004.

作者信息

Tetsche M S, Nørgaard M, Jacobsen J, Andersen E S, Lundorff P, Blaakaer J, Sørensen H T

机构信息

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Eur J Gynaecol Oncol. 2006;27(2):119-22.

PMID:16620051

Abstract

OBJECTIVE

Ovarian cancer is a serious disease with a high mortality. Our aim was to examine changes in the survival of patients with ovarian cancer in Northern Denmark.

STUDY DESIGN AND SETTING

Patients (no. = 3,719) with an incident discharge diagnosis of ovarian cancer (1985-2004) from any hospital in four Danish counties (population, 1.6 million) were included and tracked for mortality through the Danish Civil Registration System. We determined survival and mortality rates stratified by age, and used Cox proportional hazard regression analyses to assess changes over time.

RESULTS

Overall survival rate improved between 1985 and 2004. One-year survival increased from 61% to 73%, and five-year survival from 30% to 38%. Compared with the period 1985-1989 the age-adjusted one-year mortality rate ratio (MRR) was 0.65 (2000-2004) and the age-adjusted five-year MRR was 0.80 (1995-1999). The improvement was most pronounced in patients older than 40 years.

CONCLUSION

The survival of ovarian cancer patients has improved in Denmark in recent decades. This change may be the result of improved treatment.

摘要

目的

卵巢癌是一种死亡率很高的严重疾病。我们的目的是研究丹麦北部卵巢癌患者生存率的变化。

研究设计与背景

纳入了丹麦四个县（人口160万）任何一家医院确诊为卵巢癌（1985 - 2004年）的患者（n = 3719例），并通过丹麦民事登记系统跟踪其死亡率。我们确定了按年龄分层的生存率和死亡率，并使用Cox比例风险回归分析来评估随时间的变化。

结果

1985年至2004年期间总体生存率有所提高。一年生存率从61%提高到73%，五年生存率从30%提高到38%。与1985 - 1989年期间相比，年龄调整后的一年死亡率比（MRR）在2000 - 2004年为0.65，年龄调整后的五年MRR在1995 - 1999年为0.80。这种改善在40岁以上的患者中最为明显。