视黄酸X受体β：一种共调节因子，可增强视黄酸、甲状腺激素和维生素D受体与其相应反应元件的结合。

RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.

作者信息

Yu V C, Delsert C, Andersen B, Holloway J M, Devary O V, Näär A M, Kim S Y, Boutin J M, Glass C K, Rosenfeld M G

机构信息

Eukaryotic Regulatory Biology Program, University of California, San Diego.

出版信息

Cell. 1991 Dec 20;67(6):1251-66. doi: 10.1016/0092-8674(91)90301-e.

DOI:10.1016/0092-8674(91)90301-e

PMID:1662118

Abstract

The retinoic acid receptor (RAR) requires coregulators to bind effectively to response elements in target genes. A strategy of sequential screening of expression libraries with a retinoic acid response element and RAR identified a cDNA encoding a coregulator highly related to RXR alpha. This protein, termed RXR beta, forms heterodimers with RAR, preferentially increasing its DNA binding and transcriptional activity on promoters containing retinoic acid, but not thyroid hormone or vitamin D, response elements. Remarkably, RXR beta also heterodimerizes with the thyroid hormone and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXR alpha also forms heterodimers with these receptors. These observations suggest that retinoid X receptors meet the criteria for biochemically characterized cellular coregulators and serve to selectively target the high affinity binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate DNA response elements.

摘要

维甲酸受体（RAR）需要共调节因子才能有效地与靶基因中的反应元件结合。一种用维甲酸反应元件和RAR对表达文库进行序列筛选的策略，鉴定出了一个编码与RXRα高度相关的共调节因子的cDNA。这种蛋白质被称为RXRβ，它与RAR形成异二聚体，优先增强其对含有维甲酸反应元件而非甲状腺激素或维生素D反应元件的启动子的DNA结合和转录活性。值得注意的是，RXRβ还能与甲状腺激素受体和维生素D受体形成异二聚体，增强它们在各自反应元件上的DNA结合和转录功能。RXRα也能与这些受体形成异二聚体。这些观察结果表明，类视黄醇X受体符合经生物化学鉴定的细胞共调节因子的标准，并有助于选择性地靶向维甲酸、甲状腺激素和维生素D受体与其同源DNA反应元件的高亲和力结合。