人类海马体中胶质纤维酸性蛋白阳性星形胶质细胞与年龄的相关性。

Correlation between glial fibrillary acidic protein-positive astrocytes and age in the human hippocampus.

作者信息

Takahashi Tohru, Amano Naoji, Asamura Hideki, Nomiyama Tetsuo, Hanihara Tokiji, Nakayama Jun, Fukushima Hirofumi

机构信息

Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

出版信息

Leg Med (Tokyo). 2006 May;8(3):161-5. doi: 10.1016/j.legalmed.2006.01.002. Epub 2006 Apr 18.

DOI:10.1016/j.legalmed.2006.01.002

PMID:16621651

Abstract

The hippocampus is one of the areas most vulnerable to histopathological changes, and such changes may yield useful information in forensic medicine. We found that glial fibrillary acidic protein (GFAP)-positive astrocytes are frequently found in the hippocampus of consecutive series of forensic brains, distributed predominantly in the hippocampal CA4 and hippocampal sulcus (HS) regions. The present study counted GFAP-positive astrocytes in these regions and investigated associations with age, cause of death and postmortem time. Significant correlations were found between age and number of GFAP-positive astrocytes in both CA4 and HS regions. Number of GFAP-positive astrocytes increases in an age-dependent manner, but no correlations were noted between number of GFAP-positive astrocytes and postmortem time and cause of death. Number of GFAP-positive astrocytes in the hippocampus may provide useful information for age estimation.

摘要

海马体是最易发生组织病理学变化的区域之一，此类变化可能会为法医学提供有用信息。我们发现，在连续一系列法医脑标本的海马体中经常能发现胶质纤维酸性蛋白（GFAP）阳性星形胶质细胞，主要分布在海马体CA4区和海马沟（HS）区域。本研究对这些区域的GFAP阳性星形胶质细胞进行了计数，并调查了其与年龄、死因和死后时间的关联。在CA4区和HS区，年龄与GFAP阳性星形胶质细胞数量之间均存在显著相关性。GFAP阳性星形胶质细胞数量呈年龄依赖性增加，但未发现GFAP阳性星形胶质细胞数量与死后时间及死因之间存在相关性。海马体中GFAP阳性星形胶质细胞数量可能为年龄估计提供有用信息。