Singh Anamika, Trivedi R, Kashyap V K
National DNA Analysis Center, Central Forensic Science Laboratory, Kolkata, India.
Leg Med (Tokyo). 2006 May;8(3):191-3. doi: 10.1016/j.legalmed.2006.01.003. Epub 2006 Apr 18.
The study presents allele frequency data at 15 tetrameric short tandem repeat (STR) loci (D3S1358, THO1, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, CSF1PO, vWA, D8S1179, TPOX, D2S1338, D19S433 and FGA) in three ethnic populations--Mahishya, Bauri and Namasudra of Bengal to evaluate their utility in Forensic testing and understanding population structure and dynamics. A total of 169 individuals were studied from the selected populations. On an average the combined power of discrimination and power of exclusion in these groups was found 0.97 and 0.99, respectively. The allele distribution pattern shows possible genetic admixture between these ethnic groups which could be attributed to their close geographical proximity and occupying almost similar position in the social hierarchy. This study suggests that the 13 Combined DNA Index System (CODIS) markers and two added markers named D2S1338, D19S433 are highly informative and therefore suitable in matching biological specimen in human identification and population genetic study.
该研究展示了孟加拉的三个族群——马希什亚族、鲍里族和纳马苏德拉族在15个四聚体短串联重复序列（STR）位点（D3S1358、THO1、D21S11、D18S51、D5S818、D13S317、D7S820、D16S539、CSF1PO、vWA、D8S1179、TPOX、D2S1338、D19S433和FGA）的等位基因频率数据，以评估其在法医检测中的效用，并了解群体结构和动态。总共对从选定群体中选取的169个人进行了研究。平均而言，这些群体中的鉴别力联合概率和排除力联合概率分别为0.97和0.99。等位基因分布模式显示这些族群之间可能存在基因混合，这可能归因于它们地理位置接近，且在社会等级制度中占据几乎相似的地位。这项研究表明，13个联合DNA索引系统（CODIS）标记以及另外两个标记D2S1338、D19S433信息量大，因此适用于人类身份识别和群体遗传学研究中的生物样本匹配。
Zotero 插件