小于胎龄儿出生时的体脂以及胰岛素、脂联素、瘦素和胰岛素样生长因子-I的脐血水平。

Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants.

作者信息

Martínez-Cordero Claudia, Amador-Licona Norma, Guízar-Mendoza Juan Manuel, Hernández-Méndez Javier, Ruelas-Orozco Guillermo

机构信息

Departamento de Nutrición, UMAE, León, Guanajuato, Mexico.

出版信息

Arch Med Res. 2006 May;37(4):490-4. doi: 10.1016/j.arcmed.2005.11.004.

DOI:10.1016/j.arcmed.2005.11.004

PMID:16624648

Abstract

BACKGROUND

Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth.

METHODS

We performed a transverse comparative study in SGA and appropriate-for-gestational-age (AGA) infants. The study was conducted at the Hospital of Gynecology and Obstetrics in Leon, Mexico. Weight, length, and percent of body fat were evaluated during the first 48 h of birth. Glucose, insulin, leptin, adiponectin, and IGF-I levels in cord blood were measured.

RESULTS

We studied 100 infants (50 SGA and 50 AGA). A history of diabetes in a second-degree relative was higher in SGA infants than in AGA infants (48.0 vs. 30.0%, respectively; p = 0.03). Glucose, adiponectin, insulin and IGF-I levels were similar between the groups. Leptin levels and percentage of body fat were lower in SGA than AGA (15.3 vs. 23.4 ng/mL; p = 0.003, 11.1 vs. 12.7%; p <0.001, respectively). Logistic regression analysis showed that length, percentage of body fat, and leptin levels were positively associated with birthweight. However, leptin levels were not independent of percentage of body fat.

CONCLUSIONS

Low body fat and leptin levels, but no evidence of increased metabolic risk at birth, were found in SGA infants.

摘要

背景

低出生体重与成年后肥胖、胰岛素抵抗和糖尿病风险增加有关。本研究的目的是评估小于胎龄（SGA）婴儿出生时的胰岛素样生长因子-I（IGF-I）、脂联素、胰岛素水平和体脂情况。

方法

我们对SGA婴儿和适于胎龄（AGA）婴儿进行了横向比较研究。该研究在墨西哥莱昂的妇产科医院进行。在出生后的头48小时内评估体重、身长和体脂百分比。测量脐血中的葡萄糖、胰岛素、瘦素、脂联素和IGF-I水平。

结果

我们研究了100名婴儿（50名SGA婴儿和50名AGA婴儿）。SGA婴儿二级亲属中有糖尿病史的比例高于AGA婴儿（分别为48.0%和30.0%；p = 0.03）。两组之间的葡萄糖、脂联素、胰岛素和IGF-I水平相似。SGA婴儿的瘦素水平和体脂百分比低于AGA婴儿（分别为15.3 ng/mL对23.4 ng/mL；p = 0.003，11.1%对12.7%；p <0.001）。逻辑回归分析表明，身长、体脂百分比和瘦素水平与出生体重呈正相关。然而，瘦素水平并非独立于体脂百分比。