乙醛脱氢酶2启动子多态性对酒精中毒风险没有影响。
ALDH2 promoter polymorphism has no effect on the risk for alcoholism.
作者信息
Kimura Mitsuru, Kimura Shigeko, Matsushita Sachio, Kashima Haruo, Higuchi Susumu
机构信息
National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan.
出版信息
Alcohol Alcohol. 2006 Jul-Aug;41(4):368-71. doi: 10.1093/alcalc/agl028. Epub 2006 Apr 19.
AIM
To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism.
METHODS
Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed.
RESULTS
There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms.
CONCLUSION
These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.
目的
检测线粒体乙醛脱氢酶（ALDH2）启动子多态性与酒精中毒之间可能存在的关联。
方法
对515例酒精中毒患者和361例正常对照者进行基因分型以鉴定多态性。
结果
酒精中毒患者和正常对照者中-357A/G多态性的基因型和等位基因频率无显著差异。在启动子和第12外显子多态性之间观察到连锁不平衡。
结论
这些结果表明ALDH2启动子多态性不影响酒精中毒风险。
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