Calistri Elisabetta, Tiribelli Mario, Battista Marta, Michelutti Angela, Corbellino Mario, Viale Pierluigi, Fanin Renato, Damiani Daniela
Division of Hematology and Bone Marrow Transplantation, University Hospital, Udine, Italy.
Am J Hematol. 2006 May;81(5):355-7. doi: 10.1002/ajh.20560.
Epstein-Barr virus (EBV) infection and reactivation is an increasing complication in immune deficient patients, particularly after allogeneic hematopoietic stem cell transplantation (HSCT). Therapy with anti-thymocyte globulin (ATG) is associated with higher incidence of EBV-related disease in HSCT patients, but this risk is not documented in patients receiving ATG for severe aplastic anemia (SAA). We describe the case of a patient who developed an EBV infection, with the clinical features of an infectious mononucleosis, after immune suppression with cyclosporine and two courses of ATG for SAA.
爱泼斯坦-巴尔病毒（EBV）感染及再激活在免疫缺陷患者中是一种日益常见的并发症，尤其是在异基因造血干细胞移植（HSCT）后。抗胸腺细胞球蛋白（ATG）治疗与HSCT患者中EBV相关疾病的较高发病率相关，但在接受ATG治疗的重型再生障碍性贫血（SAA）患者中，这种风险尚无记录。我们描述了一例患者，其在因SAA接受环孢素和两个疗程的ATG免疫抑制后，发生了EBV感染，伴有传染性单核细胞增多症的临床特征。
