一名接受抗胸腺细胞球蛋白治疗的重型再生障碍性贫血患者发生了爱泼斯坦-巴尔病毒再激活。
Epstein-Barr virus reactivation in a patient treated with anti-thymocyte globulin for severe aplastic anemia.
作者信息
Calistri Elisabetta, Tiribelli Mario, Battista Marta, Michelutti Angela, Corbellino Mario, Viale Pierluigi, Fanin Renato, Damiani Daniela
机构信息
Division of Hematology and Bone Marrow Transplantation, University Hospital, Udine, Italy.
出版信息
Am J Hematol. 2006 May;81(5):355-7. doi: 10.1002/ajh.20560.
Epstein-Barr virus (EBV) infection and reactivation is an increasing complication in immune deficient patients, particularly after allogeneic hematopoietic stem cell transplantation (HSCT). Therapy with anti-thymocyte globulin (ATG) is associated with higher incidence of EBV-related disease in HSCT patients, but this risk is not documented in patients receiving ATG for severe aplastic anemia (SAA). We describe the case of a patient who developed an EBV infection, with the clinical features of an infectious mononucleosis, after immune suppression with cyclosporine and two courses of ATG for SAA.
爱泼斯坦-巴尔病毒（EBV）感染及再激活在免疫缺陷患者中是一种日益常见的并发症，尤其是在异基因造血干细胞移植（HSCT）后。抗胸腺细胞球蛋白（ATG）治疗与HSCT患者中EBV相关疾病的较高发病率相关，但在接受ATG治疗的重型再生障碍性贫血（SAA）患者中，这种风险尚无记录。我们描述了一例患者，其在因SAA接受环孢素和两个疗程的ATG免疫抑制后，发生了EBV感染，伴有传染性单核细胞增多症的临床特征。
Zotero 插件