Fusi Luca, Cloke Brianna, Brosens Jan J
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):479-91. doi: 10.1016/j.bpobgyn.2006.02.001. Epub 2006 Apr 21.
Magnetic resonance imaging has revealed that the endometrio-myometrial interface constitutes a distinct, hormone-dependent uterine compartment termed the junctional zone. In the non-pregnant uterus, highly specialized contraction waves originate exclusively from the junctional zone and participate in the regulation of diverse reproductive events, such as sperm transport, embryo implantation, and menstrual shedding. Conversely, growing evidence suggests that disruption of the normal endometrio-myometrial interface plays an integral role in diverse reproductive disorders. This chapter reviews our current understanding of the mechanisms that govern the cyclic changes in the uterine junctional zone and summarizes the evidence implicating the endometrio-myometrial interface in normal uterine physiology and pathological processes.
磁共振成像显示，子宫内膜-肌层界面构成了一个独特的、依赖激素的子宫腔室，称为交界区。在未孕子宫中，高度特化的收缩波仅起源于交界区，并参与多种生殖活动的调节，如精子运输、胚胎着床和月经来潮。相反，越来越多的证据表明，正常子宫内膜-肌层界面的破坏在多种生殖障碍中起着不可或缺的作用。本章回顾了我们目前对子宫交界区周期性变化调控机制的理解，并总结了子宫内膜-肌层界面在正常子宫生理和病理过程中的相关证据。
