Korbelik Mladen
British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.
Lasers Surg Med. 2006 Jun;38(5):500-8. doi: 10.1002/lsm.20337.
The outcome of the treatment of solid tumors by photodynamic therapy (PDT) is critically dependent on the contribution from the host. This host response is provoked by the rapidly induced massive tumor tissue injury delivered by PDT that is experienced as a local trauma threatening the integrity and homeostasis at the affected site.
STUDY DESIGN/MATERIALS AND METHODS: Mouse tumor models were extensively employed in pre-clinical studies investigating various aspects of host-tumor interaction following PDT, but important input was also derived from clinical data.
The recognition of this PDT-inflicted insult by innate immune sensors detecting danger signals from the distressed/altered tumor tissue, triggers host-protecting responses dominantly manifested as acute inflammation that are elicited and orchestrated by the innate immune system. To secure the affected PDT-targeted site, the inflammatory reaction attacks tumor vasculature and then neutralizes the focal source of danger signals by eliminating the injured tumor cells.
The provoked highly intensified phagocytosis of dead tumor cells occurring in the context of a vigorous innate immune reaction emerges as a key factor responsible for the development of tumor antigen-specific adaptive immune response that contributes to the eradication of PDT-treated cancers.
光动力疗法（PDT）治疗实体瘤的效果严重依赖于宿主的作用。这种宿主反应是由PDT迅速引发的大量肿瘤组织损伤所激发的，这种损伤被视为一种局部创伤，威胁着受影响部位的完整性和内环境稳定。
研究设计/材料与方法：小鼠肿瘤模型被广泛应用于临床前研究，以探究PDT后宿主与肿瘤相互作用的各个方面，但重要的信息也来自临床数据。
先天免疫传感器识别来自受损/改变的肿瘤组织的危险信号，从而认识到这种由PDT造成的损伤，触发主要表现为急性炎症的宿主保护反应，这种反应由先天免疫系统引发并协调。为了保护受影响的PDT靶向部位，炎症反应攻击肿瘤血管，然后通过清除受损的肿瘤细胞来中和危险信号的局部来源。
在强烈的先天免疫反应背景下发生的对死亡肿瘤细胞的强烈吞噬作用，成为导致肿瘤抗原特异性适应性免疫反应发展的关键因素，这有助于根除接受PDT治疗的癌症。
