类查加辛抑制剂作为寄生原生动物中半胱氨酸蛋白酶内源性调节剂的作用。 - Suppr

Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.

作者信息

Santos Camila C, Scharfstein Julio, Lima Ana Paula C de A

机构信息

Instituto de Biofisica Carlos Chagas Filho, Bloco D, sala 10-A, Universidade Federal do Rio de Janeiro, C.C.S., Cidade Universitaria, Ilha do Fundao, Rio de Janeiro, RJ, CEP 21949-900, Brazil.

出版信息

Parasitol Res. 2006 Sep;99(4):323-4. doi: 10.1007/s00436-006-0195-y. Epub 2006 Apr 25.

DOI:10.1007/s00436-006-0195-y

PMID:16636845

Abstract

摘要

相似文献

Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.类查加辛抑制剂作为寄生原生动物中半胱氨酸蛋白酶内源性调节剂的作用。

Parasitol Res. 2006 Sep;99(4):323-4. doi: 10.1007/s00436-006-0195-y. Epub 2006 Apr 25.

Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.克氏锥虫中紧密结合的半胱氨酸蛋白酶抑制剂查加辛的鉴定、特性分析及定位

J Cell Sci. 2001 Nov;114(Pt 21):3933-42. doi: 10.1242/jcs.114.21.3933.

Natural cysteine protease inhibitors in protozoa: Fifteen years of the chagasin family.原生动物中的天然半胱氨酸蛋白酶抑制剂：查加辛家族的十五年。

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Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.克氏锥虫半胱氨酸蛋白酶抑制剂查加辛的溶液结构与主链动力学

J Mol Biol. 2006 Apr 14;357(5):1511-21. doi: 10.1016/j.jmb.2006.01.064. Epub 2006 Feb 3.

Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi.恰加斯因（来自克氏锥虫的内源性半胱氨酸蛋白酶抑制剂）的晶体结构。

J Struct Biol. 2007 Feb;157(2):416-23. doi: 10.1016/j.jsb.2006.07.017. Epub 2006 Aug 17.

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.寄生虫蛋白酶抑制剂查加辛与宿主靶标半胱氨酸蛋白酶复合物的晶体结构。

J Mol Biol. 2007 Aug 3;371(1):137-53. doi: 10.1016/j.jmb.2007.05.005. Epub 2007 May 10.

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.来自克氏锥虫的半胱氨酸蛋白酶同工型，即克氏锥虫蛋白酶2和克氏锥虫蛋白酶，对底物具有不同的偏好性，并且对抑制剂的敏感性也不同。

Mol Biochem Parasitol. 2001 Apr 25;114(1):41-52. doi: 10.1016/s0166-6851(01)00236-5.

Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.寄生虫抑制剂查加辛与木瓜蛋白酶复合物的晶体结构有助于确定其广泛反应性的结构要求以及靶蛋白酶的特异性决定因素。

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Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells.查加辛是克氏锥虫的内源性半胱氨酸蛋白酶抑制剂，可调节寄生虫的分化以及对哺乳动物细胞的侵袭。

J Cell Sci. 2005 Mar 1;118(Pt 5):901-15. doi: 10.1242/jcs.01677. Epub 2005 Feb 15.

Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily.

FEBS Lett. 1995 Aug 14;370(1-2):101-4. doi: 10.1016/0014-5793(95)00798-e.

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Inhibitory Activity of Compounds Obtained from Against .从……获得的化合物对……的抑制活性。你提供的原文内容不完整，可能会影响准确理解和完整翻译，你可以补充完整后继续让我翻译。

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A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.伯氏疟原虫的一种半胱氨酸蛋白酶抑制剂对外红细胞发育至关重要。

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Identification and characterization of the second cysteine protease inhibitor of Clonorchis sinensis (CsStefin-2).鉴定和表征华支睾吸虫的第二种半胱氨酸蛋白酶抑制剂（CsStefin-2）。

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Cysteine protease inhibitor (AcStefin) is required for complete cyst formation of Acanthamoeba.半胱氨酸蛋白酶抑制剂（AcStefin）是棘阿米巴完全形成包囊所必需的。

Eukaryot Cell. 2013 Apr;12(4):567-74. doi: 10.1128/EC.00308-12. Epub 2013 Feb 8.

The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi.实验性恰加斯病中的激肽释放酶-激肽系统：研究炎症性水肿对克氏锥虫宿主细胞入侵 GPCR 介导途径影响的范例。

Front Immunol. 2013 Jan 25;3:396. doi: 10.3389/fimmu.2012.00396. eCollection 2012.

Microbial and fungal protease inhibitors--current and potential applications.微生物和真菌蛋白酶抑制剂——当前和潜在的应用。

Appl Microbiol Biotechnol. 2012 Feb;93(4):1351-75. doi: 10.1007/s00253-011-3834-x. Epub 2012 Jan 5.

The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a homohexamer and belongs to the M17 family of metallopeptidases.克氏锥虫主要亮氨酰氨基肽酶（LAPTc）组装成同源六聚体，属于 M17 家族的金属肽酶。

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Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.红细胞外疟原虫分泌一种半胱氨酸蛋白酶抑制剂，参与子孢子入侵，并能够阻止宿主肝细胞的细胞死亡。

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本文引用的文献

Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.克氏锥虫半胱氨酸蛋白酶抑制剂查加辛的溶液结构与主链动力学

J Mol Biol. 2006 Apr 14;357(5):1511-21. doi: 10.1016/j.jmb.2006.01.064. Epub 2006 Feb 3.

Identification of EhICP1, a chagasin-like cysteine protease inhibitor of Entamoeba histolytica.溶组织内阿米巴的类查加辛半胱氨酸蛋白酶抑制剂EhICP1的鉴定。

FEBS Lett. 2005 Mar 14;579(7):1573-8. doi: 10.1016/j.febslet.2005.01.067.

J Cell Sci. 2005 Mar 1;118(Pt 5):901-15. doi: 10.1242/jcs.01677. Epub 2005 Feb 15.

A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.利什曼原虫半胱氨酸肽酶抑制剂ICP在宿主与寄生虫相互作用中的潜在作用。

Mol Microbiol. 2004 Dec;54(5):1224-36. doi: 10.1111/j.1365-2958.2004.04355.x.

Cystatins.胱抑素

Biochem Soc Symp. 2003(70):179-99. doi: 10.1042/bss0700179.

Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens.

FEBS Lett. 2003 May 8;542(1-3):12-6. doi: 10.1016/s0014-5793(03)00327-2.

Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors.查加辛家族中的序列保守性表明，不相关的蛋白质抑制剂在结合半胱氨酸蛋白酶方面存在共同趋势。

Protein Sci. 2002 Aug;11(8):1971-7. doi: 10.1110/ps.0207202.

Cysteine proteases of parasitic organisms.寄生生物的半胱氨酸蛋白酶。

Mol Biochem Parasitol. 2002 Mar;120(1):1-21. doi: 10.1016/s0166-6851(01)00438-8.

J Cell Sci. 2001 Nov;114(Pt 21):3933-42. doi: 10.1242/jcs.114.21.3933.

The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer.

FEBS Lett. 2001 Aug 24;504(1-2):41-4. doi: 10.1016/s0014-5793(01)02753-3.

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Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.

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