[作为人类癌症分子标志物的鲽鱼降钙素-1（STC-1）]

[Stanniocalcin-1 (STC-1) as a molecular marker for human cancer].

作者信息

Koide Yoshio, Sasaki Takeshi

机构信息

Department of Infection Control and Laboratory Diagnostics, Tohoku University, Graduate School of Medicine, Sendai 980-8574.

出版信息

Rinsho Byori. 2006 Mar;54(3):213-20.

PMID:16637567

Abstract

Stanniocalcin (STC) is a glycoprotein hormone that regulates calcium levels in fish. The related human protein stanniocalcin-1 (STC-1) is expressed in multiple organs including the ovary, prostate, kidney, and thyroid. Human STC-1 expression is enhanced by neural cell differentiation, bone formation, and cell proliferation. Recently, quantitative RT-PCR analysis showed high levels of STC-1 mRNA in the blood of patients with cancer as compared with those in the blood of volunteers without cancer. The STC-1 mRNA expression in blood is closely related to tumor size in breast cancer, micrometastases of hepatocellular carcinoma, and minimal residual disease in leukemia. This brief review describes the diagnostic significance of STC-1 as a molecular marker for human cancer.

摘要

鲽源钙调蛋白（STC）是一种调节鱼类钙水平的糖蛋白激素。相关的人类蛋白鲽源钙调蛋白-1（STC-1）在包括卵巢、前列腺、肾脏和甲状腺在内的多个器官中表达。神经细胞分化、骨形成和细胞增殖可增强人类STC-1的表达。最近，定量逆转录聚合酶链反应（RT-PCR）分析显示，与无癌志愿者的血液相比，癌症患者血液中的STC-1 mRNA水平较高。血液中STC-1 mRNA的表达与乳腺癌的肿瘤大小、肝细胞癌的微转移以及白血病的微小残留病密切相关。这篇简短的综述描述了STC-1作为人类癌症分子标志物的诊断意义。