Maeda Jun, Higuchi Makoto, Suhara Tetsuya
Brain Imaging Project, National Institute of Radiological Sciences, Anagawa, Chiba, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Feb;26(1):17-21.
Recently, it has been indicated that glial cells play as important role in the development of neurodegenerative disorders. Expression of peripheral benzodiazepine receptor (PBR) has higher localization in the glial cells than in the neural cells, and is a noticeable marker for gliosis produced by neurodegeneration. In vivo imaging of PBR has been attempted by [11C]PK11195 positron emission tomography (PET), and it has been documented that the [11C]PK11195 binding potential increases in various neurodegenerative disorders such as Alzheimer's disease and stroke. Furthermore, we have succeeded in developing new positron ligands [11C]DAA1106 and [18F]fluoroethyl-DAA1106 for visualization of PBRs, which have higher accumulation in the brain than [11C]PK11195. We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders.
最近，有研究表明神经胶质细胞在神经退行性疾病的发展中起着重要作用。外周苯二氮䓬受体（PBR）在神经胶质细胞中的表达定位高于神经细胞，是神经变性所致神经胶质增生的一个显著标志物。已尝试通过[11C]PK11195正电子发射断层扫描（PET）对PBR进行体内成像，并且有文献记载，在诸如阿尔茨海默病和中风等各种神经退行性疾病中，[11C]PK11195结合潜能会增加。此外，我们已成功开发出用于可视化PBR的新型正电子配体[11C]DAA1106和[18F]氟乙基-DAA1106，它们在脑中的蓄积高于[11C]PK11195。我们得出结论，通过PBR配体进行PET成像对神经退行性疾病的诊断是有用的。
