一种基于活性的木瓜蛋白酶家族半胱氨酸蛋白酶二肽基肽酶I/组织蛋白酶C的选择性探针。
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.
作者信息
Yuan Fang, Verhelst Steven H L, Blum Galia, Coussens Lisa M, Bogyo Matthew
机构信息
Department of Pathology, and Microbiology & Immunology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
出版信息
J Am Chem Soc. 2006 May 3;128(17):5616-7. doi: 10.1021/ja060835v.
PMID:16637611
Abstract
Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.
摘要
二肽基肽酶I通过去除N端前二肽参与多种疾病相关蛋白酶的激活。我们在此报告一种基于活性的选择性探针，用于监测全蛋白质组以及完整细胞中二肽基肽酶I的活性，而无需标记密切相关的酶家族成员。
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