Khambadkone Sachin, Bonhoeffer Philipp
Department of Cardiology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006:23-8. doi: 10.1053/j.pcsu.2006.02.006.
Percutaneous implantation of valves is a fast evolving field in interventional cardiology. Acquired pulmonary valve disease is uncommon; however, right ventricular outflow tract dysfunction is one of the common indications of reoperations during late follow-up of repaired congenital heart disease. The impact of pulmonary valvular dysfunction on right ventricular function during late follow-up of patients with adult congenital heart disease has led to earlier intervention. The importance of a technique with lower morbidity and mortality, good patient acceptance, and efficacy that is comparable with surgery cannot be underestimated. Percutaneous pulmonary valve implantation uses a valved-stent assembly implanted by means of a double balloon catheter delivery system. The device is a bovine jugular venous valve sutured inside a platinum-iridium. In a series of 58 consecutive patients, we implanted this valve successfully with good clinical and hemodynamic results and no mortality on long-term follow-up. Early device designs led to reintervention by surgical explantation in the early experience, and a second percutaneous pulmonary valve implantation during latter experience. This exciting new technique will lead to review of the current indications and timing of intervention for right ventricular outflow tract dysfunction in late follow-up of congenital heart disease.
经皮瓣膜植入术是介入心脏病学中一个快速发展的领域。获得性肺动脉瓣疾病并不常见;然而,右心室流出道功能障碍是先天性心脏病修复术后晚期随访期间再次手术的常见指征之一。在成人先天性心脏病患者的晚期随访中,肺动脉瓣功能障碍对右心室功能的影响促使了更早的干预。一种发病率和死亡率较低、患者接受度良好且疗效与手术相当的技术的重要性不可低估。经皮肺动脉瓣植入术使用通过双球囊导管输送系统植入的带瓣支架组件。该装置是一个缝合在铂铱合金内的牛颈静脉瓣膜。在连续的58例患者中,我们成功植入了该瓣膜,临床和血流动力学结果良好,长期随访无死亡病例。早期的器械设计在早期经验中导致通过外科取出进行再次干预,而在后期经验中则进行了第二次经皮肺动脉瓣植入。这项令人兴奋的新技术将促使人们重新审视先天性心脏病晚期随访中右心室流出道功能障碍的当前干预指征和时机。